Question

Differentiation of tissues and organs is connected with

• A. Differential expression of genes
• B. Deletion of genes
• C. Lethal mutations
• D. Developmental mutations

Answer 1

The correct option is A Differential expression of genes

Mutations that adversely affect the survival of organisms are called as lethal mutations. Removal of one or more nucleotide bases to the DNA segment is known as deletion. Lethal mutations and deletions are not determinant of organ/tissues differentiation which makes options C and B incorrect. Developmental mutations are the one that affects differentiation of different embryonic structures into specific structures and pattern according to their position in the body and thus are used to study tissues specific gene expression; option D is incorrect. Differential expression of different genes at different stages of development leads to organ and tissues differentiation, for example, size and pattern of puffs of polytene chromosomes, which are the site of transcription, varies at different developmental stages, indicating differential gene activity. The correct option is A.