Question

Disorder in which B-lymphocytes and
T-lymphocytes are not formed is

• A. Muscular dystrophy
• B. SCID
• C. Cystic fibrosis
• D. AIDS

Answer 1

The correct option is B SCID

AIDS
AIDS (Acquired ImmunoDeficiency Syndrome) is caused by HIV (Human Immunodeficiency Virus). It mainly affects the immune system of the human body by infecting macrophages followed by helper T cells, thus resulting in weak immunity.

SCID
● Severe Combined ImmunoDeficiency Syndrome (SCID) is a disorder caused by a mutation in gene encoding for the enzyme adenosine deaminase (ADA).

● Lack of ADA gene results in depletion of T-lymphocytes and it affects the activation of B cells as well. Besides, development of B cells also gets affected.

Cystic fibrosis
Cystic fibrosis is a disease in which mutations occur in gene encoding CFTR (chloride ion channels) resulting in malfunctioning CFTR channels on the lung epithelial cells.
This affects the movement of chloride ions from the cells to outside, eventually leading to absence of hydration of the cell surface.
● Thus, causing thickening of mucus and problems in breathing.
● It does not involve B and T lymphocytes.

Muscular dystrophy
Muscular dystrophy is a genetic disorder in which mutation occurs in the genes encoding proteins involved in providing the structure and function of healthy muscle. This results in muscular degeneration.

Final answer:
(b) SCID