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Question

DNA glycosylase is an enzyme involved in the base excision repair. The function is

A
Addition of correct base
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B
Addition of correct nucleotide
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C
Removal of incorrect base
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D
Removal of phosphodiester bond
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Solution

The correct option is C Removal of incorrect base
The enzyme DNA glycosylase is involved in base-excision repair mechanism of DNA repair. This mechanism involves removal of a damaged nucleotide base and excision of a short piece of the polynucleotide which is followed by resynthesis with DNA polymerase. The enzyme DNA glycosylase cleaves the N-glycosidic bond instead of cleaving phosphodiester bond. This liberates the altered base and an apyrimidinic or apurinic site called AP site is generated which is then repaired by AP endonuclease repair pathway.
So, the correct answer is 'Removal of incorrect base'.

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