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Question

DNA strands are antiparallel because of

A
Phosphodiester bonds
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B
Disulphide bonds
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C
Peptide bonds
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D
H-bonds
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Solution

The correct option is A Phosphodiester bonds
Answer

Peptide bonds
Peptide bonds link the adjacent amino acids in a polypeptide chain.

Disulphide bonds
S-S bonds or disulphide bonds are present between the sulphur containing amino acids in a protein. They help in stabilising the folded polypeptide chain to form secondary, tertiary or quaternary structures.

H-bonds
H_bonds or hydrogen bonds are present between the complementary bases on the two strands of DNA and hold the two strands together. Adenine pairs with thymine using 2 hydrogen bonds and cytosine pairs with guanine using 3 hydrogen bonds. These bonds do not have any polarity and are not responsible for the antiparallel nature of the DNA strands.

Phosphodiester bonds

.The phosphodiester bonds join the adjacent nucleotides in the DNA strands.
. The two strands of DNA run antiparallel because one strand runs from 53’ direction and the other strand runs from 35’.

.In the 5’- 3’ strand the nucleotides are so arranged that the phosphodiester bond forms between the 3’OH group of one nucleotide and the 5’ phosphate group of the next.

.Thus, the 53’ strand has a free 5’ phosphate group in the first nucleotide and a free 3’ OH group in the last nucleotide.

.In the 35’ strand the nucleotides are so arranged that the phosphodiester bond forms between the 5’phosphate group of one nucleotide and the 3’ OH group of the next.

.Thus, the 3’- 5’ strand has a free 3’ OH in the first nucleotide and a free 5’ phosphate group in the last nucleotide.

.Thus, phosphodiester bonds are responsible for the antiparallel nature


Final answer

d. Phosphodiester bonds

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