Question

Do sister chromatids participate in spindle assembly?

Answer 1

Sister Chromatids:

1. Sister chromatids, which are connected by a structure known as the centromere, are two identical copies of the same chromosome that are created by DNA replication.
2. They have split apart during cell division, with one copy of each chromosome going to each daughter cell.

Spindle Assembly:

By avoiding chromosome missegregation, the mitotic or spindle assembly checkpoint contributes to the preservation of genomic integrity.

Participation of Sister chromatids in Spindle assembly:

1. In the construction and operation of the spindle, the sister chromatids play an active role.
2. Each chromatid is attached to microtubules that are attached to a spindle pole by a multiprotein complex called the kinetochore.
3. Additionally, the kinetochore's proteins contribute to the creation of the forces that propel chromosomal movement.
4. Microtubule growth and spindle assembly are also regulated by motors and microtubule-regulatory proteins found in the chromatid arms.
5. Sister chromatids participate in spindle assembly.