Acinar cells and duct cells make up the exocrine pancreas. Pancreatitis, a painful inflammation brought on by a variety of environmental (injury, alcohol, a high-fat diet, etc.) or hereditary (for instance, cystic fibrosis) reasons, is the most typical damage to the exocrine pancreas.
Models of pancreatitis have been linked to two different types of regeneration49 In the traditional regeneration mode, pre-existing acinar cells are multiplied to create new acinar cells The degranulated and duct-like acinar cells are thought to "redifferentiate" and return to a normal and functioning acinar state in the second regeneration mode. Since a lineage marker was not used to follow the dedifferentiated acinar cells, their redifferentiation was assumed.
Acinar cells, which produce and secrete digestive enzymes, ductal cells, which channel the enzymes into the small intestine, and central acinar cells make up the exocrine pancreas. Both in animals and people, the exocrine pancreas is capable of vigorous and spontaneous regeneration.
The pancreas has a limited potential to regenerate, according to research, and this ability diminishes with age.