The correct option is E Teratogens
Teratogens are agents that can disturb the development of an embryo or fetus. Teratogens may cause a birth defect in the child (congenital abnormalities). Tranquilizer and sedatives are drug used to reduce anxiety. Nicotine is a potent parasympathomimetic alkaloid.
Thus, the correct answer is 'Teratogens'.