Question

During glycolysis, enzyme hexokinase changes glucose to glucose-6-phosphate. Hexokinase is inhibited by

• A. Feedback inhibition
• B. Positive feedback
• C. Competitive inhibition
• D. Non-competitive inhibition

Answer 1

The correct option is A Feedback inhibition

Accumulation of glucose-6-phosphate will lead to inhibition of hexokinase as hexokinase is an allosteric enzyme and the product, i.e., glucose-6-phosphate is an allosteric modulator or inhibitor of the enzyme. This type of inhibition is called as feedback inhibition.