The correct option is A Histamine
Histamine is released by the mast cells during injury or wounds which causes the surrounding blood vessels to dilate and increase in permeability. This allows fluid and cells of the immune system, such as leukocytes and blood plasma proteins, to leak from the bloodstream through the vessel walls and migrate to the site of tissue injury or infection, where they begin to fight the infection and nourish and heal the injured tissues. Hence, options A is correct.