Question

During mitosis, it is necessary for the nuclear envelope of the parent cell to dissolve. This is accomplished, at least in part, by phosphorylation of proteins associated with the nuclear envelope. If the enzyme responsible for the phosphorylation event is inhibited, at which phase of mitosis are cells likely to arrest?

• A. Prophase
• B. Metaphase
• C. Telophase
• D. Anaphase

Answer 1

The correct option is A Prophase

During mitosis, it is necessary for the nuclear envelope of the parent cell to disintegrate. This is accomplished in part by phosphorylation of proteins associated with the nuclear envelope. If the enzyme responsible for that phosphorylation event is inhibited, cells are likely to arrest during prometaphase. Prometaphase is when the nuclear envelope breaks down and releases the sister chromatids from the nucleus. Phosphorylation process is necessary for these events, so cell gets arrested in prophase.
Therefore, the correct answer is option 'a'.