Question

During the acylation of an aliphatic primary amine, which of the following is replaced by an acyl group?

• A. One H atom of $N{H}_2$ group
• B. Both H atom of $N{H}_2$ group
• C. Alkyl group of the amine
• D. $N{H}_2$ group

Answer 1

The correct option is A One H atom of $N{H}_2$ group

Aliphatic and aromatic $1^o$ and $2^o$ amines react with acid chlorides by nucleophilic substitution, where the H atom of $N{H}_2$ group is replaced by the acyl group.
Nitrogen-containing compounds with the help of benzyl chloride and aqueous sodium hydroxide. Pyridine can also be used as an alternative to the sodium hydroxide base.
The reaction is as follows:
$RN{H}_2+R^{\prime }COCl\to RNHCO{R}^{\prime }+HCl$
Here, R = Ph and R' = $C{H}_3$
So, product formed will be $PhNHCOC{H}_3$.
This is commonly known as acetanilide.
Hence, option (b) is correct.