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Question

During the oxidation of FADH2, _________ is not involved.

A
complex I
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B
complex II
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C
complex III
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D
complex IV
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Solution

The correct option is A complex I
During the oxidation of FADH2, complex I is not involved. During the oxidation of FADH2, complex II, III and IV are involved.

FADH2 undergoes oxidation and releases electrons to the iron-sulfur protein of complex II. From complex II, electrons are transferred to ubiquinone. The ubiquinone gets reduced to form ubiquinol. The electrons from ubiquinol are transferred to the cytochrome b and cytochrome c1 of complex III. The electrons are then further transferred to cytochrome c. Cytochrome c is a small protein attached to the outer surface of the inner membrane of mitochondria and acts as a mobile carrier for the transfer of electrons between complex III and IV. In complex IV, the electrons pass through cytochromes a and a3. From complex IV, electrons pass to oxygen.
Oxygen is the final acceptor of the electrons which combines with H+ to form water.

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