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Question

Each immunoglobin has two heavy chains and two light chains .The antigen binding site is found in

A
Variable region of heavy chain
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B
Variable region of light chain
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C
Constant region of light chain
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D
Variable region of both heavy and light chain
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Solution

The correct option is D Variable region of both heavy and light chain
Antigen binding site, also known as paratope is a part of an antibody which recognizes and binds to an antigen. It is a small region of 5 to 10 amino acids of the antibody's Fv region, part of the fragment antigen-binding (Fab region), is composed of one constant and one variable domain from each heavy and light chain of the antibody. The paratope is shaped at the amino terminal end of the antibody monomer by the variable domains from the heavy and light chains.
So, the correct answer is 'Variable region of both heavy and light chain'.

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