Enzyme a-ketoglutarate dehydrogenase brings about?

Oxidation only

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Decarboxylation only

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Reduction only

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Oxidation and decarboxylation

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Solution

The correct options are
A Oxidation only
C Reduction only
a-ketoglutarate dehydrogenase enzyme catalyzes the oxidation reaction where the substrate a-ketoglutarate is converted into succinyl Co-A and NAD is reduced to NADH when the electrons are released.
Thus it performs oxidation as well as reduction reaction.
It also belongs to the dehydrogenase class of enzyme which are a part of oxidoreductase group.
Therefore 2 options can be the correct answer for the question option A and C

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C_{3}

Refer to the given reaction.

a -Ketoglutaric acid + $N H_{4}^{+}$ + NADPH $G l u t a m a t e - -------- \to d e h y d r o g e n a s e G l u t a m a t e + H_{2} O + N A D P$

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