Question

Enzymes of TCA cycle are located in the mitochondrial matrix except one which is located in inner mitochondrial membrane in eukaryotes and in cytosol in prokaryotes. This enzyme is

• A. Succinate dehydrogenase
• B. Lactate dehydrogenase
• C. Isocitrate dehydrogenase
• D. Malate dehydrogenase

Answer 1

The correct option is A Succinate dehydrogenase

All the oxidative enzymes of TCA are located in matrix except succinic dehydrogenase. This enzyme catalyzes the conversion of succinic acid into fumaric acid. The enzyme is an integral protein complex that is tightly bound to the inner mitochondrial membrane. In fact, this enzyme is the preferred marker enzyme for inner membranes while performing mitochondrial fractionations. In prokaryotes, it is located in the cytosol.

So, the correct answer is option A.