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Excess cholesterol is responsible for ulcers.
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The decrease in the stomach's mucus lining that leads to an ulcer is usually caused by one of the following: an infection with the bacterium Helicobacter pylori (H. pylori) long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen.
When there is too much cholesterol in the blood, it builds up in the walls of arteries, causing a process called atherosclerosis, a form of heart disease.

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