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Question
Explain the autoregulatory mechanism of
GFR.
Explain the autoregulatory mechanism of GFR.
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Solution
The
mechanism by which the kidney regulates the glomerular filtration
rate is autoregulative. It is carried out by the juxtaglomerular
apparatus. Juxtaglomerular apparatus is a microscopic structure
located between the vascular pole of the renal corpuscle and the
returning distal convoluted tubule of the same nephron.
It plays a
role in regulating the renal blood flow and glomerular filtration
rate. When there is a fall in the glomerular filtration rate, it
activates the juxtaglomerular cells to release renin. This stimulates
the glomerular blood flow, thereby bringing the GFR back to normal.
Renin brings the GFR back to normal by the activation of the
renin-angiotensin mechanism.
The mechanism by which the kidney regulates the glomerular filtration rate is autoregulative. It is carried out by the juxtaglomerular apparatus. Juxtaglomerular apparatus is a microscopic structure located between the vascular pole of the renal corpuscle and the returning distal convoluted tubule of the same nephron.
It plays a role in regulating the renal blood flow and glomerular filtration rate. When there is a fall in the glomerular filtration rate, it activates the juxtaglomerular cells to release renin. This stimulates the glomerular blood flow, thereby bringing the GFR back to normal. Renin brings the GFR back to normal by the activation of the renin-angiotensin mechanism.
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