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Question

Fatty acids enter Krebs cycle as

A
pyruvate
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B
acetyl CoA
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C
oxaloacetate
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D
carbon dioxide
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Solution

The correct option is B acetyl CoA
Fats get broken down into glycerol and fatty acids. Glycerol is initially oxidised to dihydroxyacetone phosphate and is then converted to glyceraldehyde-3-phosphate with the help of isomerase enzyme. Thus fatty acids enter the glycolysis as glyceraldehyde-3-phosphate.

The resulting product of glycolysis is pyruvic acid or pyruvate which is further oxidized to acetyl CoA. Acetyl CoA enters the Krebs cycle. Acetyl Co-A is the common molecule in the respiratory pathway for all the respiratory substrates.


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