Fill in the blank with a suitable option:
A preposition is a word which comes before a noun or a pronoun and establishes a relationship between the elements of a clause or words. Option A)in spite of is correct as it is used before one fact that makes another fact interesting. The other options are wrong as because, although, and however indicate a reason, but,and despite whatever amount or degree respectively. These uses don't fit in the given question. The correct answer is A)in spite of.