The correct option is B with
A phrasal verb is an expression that is idiomatic in meaning. In other
words, the phrasal verb has a different meaning as compared to its
literal meaning.
Option B: 'With' forms a phrasal verb with 'interfere'. 'With' means 'in relation to'.
The phrase 'interfere with' in the sentence means 'to prevent something from happening or developing in a correct way'.
Hence option B is correct.
Option A: 'On' means 'to come in contact with the top of a surface'. For example, 'on the table'. It does not seem relevant here.
Option C: 'At' refers to a place or time: 'at the theatre', 'at 7p.m.'.
Option D: 'Of' refers to belonging, for example, 'the sister of my husband'.
These words do not form a complete meaning in the sentence. Hence A, C and D are incorrect.