The correct option is C from / _
The context refers to leaving work. This indicates the place where action starts.
So, the preposition 'from' in option D is correct as one leaves from work and goes home. No preposition is required before home as it is an adverb of place.
Option A is incorrect as the second filler 'to' is incorrect as the adverb of place 'home' does not take any preposition.
Option B is incorrect as the first filler needs the preposition 'from' as work is the place where the journey or the action began.
Option C is incorrect as the first filler is required and the second filler 'to' is not.
Thus, option D is correct.