The correct option is
E pursue
Option E: 'Pursue' means 'seek to attain or accomplish (a goal) over a long period of time'.
Here, the person 'you' must seek his goal (career) with all seriousness.
Hence this word forms a complete meaningful sentence and option E is correct.
Option A: 'Direct' means 'aim something in a particular direction'.
Option B: 'Complete' means 'finish making or doing'.
Option C: 'Follow' means 'go after something or someone'.
Option D: 'Manage' means 'supervise or be in charge of'.
These words do not complete the sentence in meaning.
Hence options A, B, C and D are wrong.