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Question

Find the incorrect statement/s regarding the factors affecting enzymatic activity or its inhibition
I. Product formed during a reaction can inhibit enzyme activity.
II. Competitive factors or replacement enzymes can act as inhibitors.
III. Change in the active site, can inhibit the action of enzymes.
IV. Increase in temperature (upto a limit), generally increases the rate of enzymatic activity.


A

I only

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B

II only

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C

ll & lll

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D

IV only

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E

None of these

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Solution

The correct option is E

None of these


Regarding the context, all of the above statements are true. The first two are the different methods of inhibition of the enzyme's activity. Coming to the third point, the slightest change in the active site's 3D structure or conformation, can bring about cessation in the activity of the enzyme. In fact it is also how products or other factors stop the enzyme, by binding to its active site and modifying its structure so that the substrate no longer fits the enzyme. Lastly, increase in reaction temperature as small as 1 or 2 degrees may increase activity by 10 to 20% . This is also complicated by the fact that many enzymes are adversely affected by high temperatures because most animal enzymes rapidly denature at temperatures above 40C .


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