Question

First clinical application of gene therapy was used in 1990 over a four year old girl for

• A. Adenosine deaminase deficiency
• B. Growth deficiency
• C. Adenosine deficiency
• D. Adenine deficiency

Answer 1

The correct option is A Adenosine deaminase deficiency

Gene therapy
Gene therapy is the collection of methods in which a defective gene present in the embryo or child is corrected by replacing it with a normal functional gene to compensate for the malfunctioning of the defective gene.

First gene therapy
The first gene therapy was performed in a 4- year old girl in 1990 for Severe Combined ImmunoDeficiency. She was treated with the functional copy of adenosine deaminase (ADA) gene.

Final answer:
(d) Adenosine deaminase deficiency