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Question

For an SN2 reaction of

the most effective nucleophile will be:

A
MeO
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B
Me3CO
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C
Me2CHO
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D
MeCH2O
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Solution

The correct option is A MeO
As nucleophile becomes bulkier its backside approach to the displacement site is retarded.
Hence, among the given options MeO will be the most suitable nucleophile for the SN2 reaction.

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