Question

Friedel-Craft's reaction using $MeCl$ and anhydrous $AlC{l}_3$ will take place most efficiently with:

• A. benzene
• B. nitrobenzene
• C. acetophenone
• D. toluene

Answer 1

The correct option is D toluene

Friedel-crafts reaction is an electrophile substitution reaction and presence of an electron-releasing substituent like Methyl makes the benzene nucleus more reactive towards such reaction

The nitro-benzene has electron withdrawing groups which makes it less reactive than benzene.

Thus toluene is most reactive among the given.