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Krebs Cycle

From the foll...

Question

From the following options, identify the 5C intermediate compound in the TCA cycle.

A

Citric acid

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B

Succinyl CoA

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C

α

-ketoglutaric acid

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D

Fumaric acid

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Solution

The correct option is C $α$ -ketoglutaric acid
The TCA cycle or Krebs’ cycle starts with the condensation of acetyl group with oxaloaceticacid (4C) (OAA) and water to yield citric acid (6C). The reaction is catalysed by the enzyme citrate synthetase and a molecule of CoA is released. Citrate is then isomerised to isocitrate (6C). It is followed by two successive steps of decarboxylation, leading to the formation of $α$ -ketoglutaric acid. It is 5C intermediate molecule in TCA cycle.

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Q. Match List I(compound oxidized during Krebs cycle) with List II(Compound formed on oxidation) and select the correct answer.

List-I	List-II
a. Pyruvic acid	$1$ . AcetylCoA
b. Isocitric acid	$2$ . Succinyl CoA
c. a-Ketoglutaric acid	$3$ . Oxaloacetic acid
d. Succinic acid	$4$ . Oxalosuccinic acid
	$5$ . Fumaric acid

Q. From the following options, identify the 5C intermediate compound in the TCA cycle.

The intermediate product between

α

-ketoglutaric acid and succinic acid in TCA cycle is

Q. In which of the following steps of citric acid cycle,

C O_{2}

\begin{matrix} I . C i t r i c a c i d & \to & α - k e t o g l u t a r i c a c i d I I . S u c c i n i c a c i d & \to & M a l i c a c i d I I I . M a l i c a c i d & \to & O x a l o a c e t i c a c i d I V . α - k e t o g l u t a r i c a c i d & \to & S u c c i n y l C o - A \end{matrix}

Select the correct answer using the codes given below

Q. Consider

A. alpha ketoglutaric acid

B. Succinic acid

C. Citric acid

D. Fumaric acid

E. Oxalosuccinic acid

Choose the correct order of their formation in the Krebs cycle.

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