Question

Gabriel phthalimide synthesis is used in preparation of:

• A. $1^o$ Amine
• B. $2^o$ Amine
• C. $3^o$ Amine
• D. All of the above

Answer 1

The correct option is A $1^o$ Amine

Gabriel phthalimide synthesis is a method for preparation of primary amine. The Gabriel phthalimide synthesis reaction is as follows:
Gabriel phthalimide is firstly treated with alcoholic $KOH$ to from potassium phthalimide which on further reaction with ethyl iodide gives N-Ethyl phthalimide.
The product N-Ethyl phthalimide is hydrolysed with aq. $NaOH$ to form primary amine, i.e. ethylamine. Thus option (a) is correct.