Question

Gaucher's disease is concerned with which of the following?

• A. Abnormal fat metabolism
• B. Abnormal protein metabolism
• C. Abnormal carbohydrate metabolism
• D. Abnormal vitamin metabolism

Answer 1

Answer: (A)

Abnormal fat metabolism

Gaucher's disease is an autosomal recessive inherited disorder in which glucocerebroside is not degraded and get a deposit in organs like spleen and bone marrow because the enzyme glucocerebrosidase is not able to break the lipid does not form this enzyme.

• Liver and spleen enlargement (hepatosplenomegaly).
  
• Reduction in RBCs number(anaemia).
  
• Easy bruising caused, in part, by a low level of platelets (thrombocytopenia).
  
• Bone disease (bone pain and fractures).
  
• So the correct option is 'Abnormal fat metabolism'.