The correct option is
A The change in frequency of a gene mearly by chance in small population
Genetic drift is a mechanism of evolution in which there is a variation in the relative frequency of different genotypes in a small population over generations due to chance. Chance indicates the disappearance of particular genes as individuals die or do not reproduce. Genetic drift occurs in all populations of non-infinite size, but its effects are strongest in small populations.
So, the answer is A.