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Question

Genetic mapping of bacteriophage phi x 174 has been done by


A
Pirie and Bawden
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B
F. Sanger
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C
R.L. Sinsheimer
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D
Salk and Sabin
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Solution

The correct option is C F. Sanger
F Sanger and his team, 1977 sequenced the genome of phi X 174, the first DNA-based genome to be sequenced. He used a newly introduced radiolabeling technique for mapping. Pirie and Bawden carried out isolation of TMV by crystallization. R.L. Sinsheimer carried out in vitro replication of phiX174. Salk and Sabin developed live and killed virus vaccines for polio. Thus, the correct answer is option B.

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