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Question

Genetic recombination in which a small double stranded piece of DNA is transferred from donor bacterium to recipient bacterium by a bacteriophage was first demonstrated by :

A
Griffith
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B
Lederberg and Tatum
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C
Zinder and Lederberg
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D
Avery et.al.
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Solution

The correct option is C Zinder and Lederberg
Genetic recombination in bacteriophage φX174 usually takes place early in the infection process and involves two parental replicative form (double-stranded) DNA molecules.

Zinder and Lederberg were first to demonstrate genetic recombination in which small double stranded piece of DNA is transferred from donor bacterium to recipient bacterium by a bacteriophage.

Bacterial conjugation was first described by Lederberg and Tatum in 1946 as a phenomenon involving the exchange of markers between closely related strains of Escherichia coli.

Oswald Avery's group showed that DNA was the "transforming principle." When isolated from one strain of bacteria, DNA was able to transform another strain and confer characteristics onto that second strain.

In his famous experiments, Griffith demonstrated in 1928 that the ability to synthesis a capsule and hence become virulent can be transferred from heat-inactivated “smooth” strains to living but avirulent “rough” strains of S. pneumoniae.

So the correct answer is "option c".

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