Atrial natriuretic factor(ANF) is a polypeptide hormone which reduces an expanded extracellular fluid (ECF) volume by increasing renal sodium excretion. ANF is synthesised, secreted, and released by heart muscles cells called myocytes in the atrial wall. ANF in the homeostatic control of blood pressure as well as of ECF volume. Dietary sodium restriction diminishes the peak natriuretic effect of infused ANF but does not significantly affect responses of blood pressure, heart rate, renin, or aldosterone.