Rough Endoplasmic Reticulum or RER looks like an uneven surface because of the presence of the 80S ribosomes when viewed under an electron microscope. The main function of the RER is to take part in the protein synthesis and helps in the transportation of the protein to other parts.
Smooth Endoplasmic Reticulum or SER appears to be like a smooth surface when viewed from the electron microscope, as they do not contain ribosomes. The SER plays a vital role in the production, storage, and secretion of the steroid hormones and lipids