Question

Give one issue with the use of live vaccines.

Answer 1

Live Vaccine:

1. The kind of vaccine that uses the attenuated form of germ that causes diseases is known as a live vaccine.
2. Attenuation is the process of altering an infectious agent to make it innocuous or less virulent.
3. This vaccine is formed by lowering a pathogen's virulence while keeping it alive.

Issues with the live vaccine:

1. The most serious problem with live vaccines is the chance of reversion to natural virulence through back-mutations of the attenuated organism as well as the possibility of generating clinical affection in the receiver akin to wild-virus infection.
2. The best example of a live vaccine that carries this issue is the oral polio vaccine (OPV).
3. This issue is mainly concerned with the older versions but the new generation vaccines that use stable genetic mutants are free from the problem of back mutation.