i. RBCs undergo change in shape and transform into sickle-shaped cells. ii. Oxygen transport to the tissue is reduced.
(a) Identify the disease. (b) What is the reason for this disease?
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Solution
(a) The disease is sickle-cell anaemia. (b) It occurs due to disorders in genes which results in structural deformity in the haemoglobin which decreases the oxygen holding capacity of RBC leading to anaemia.