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Question

Given below is the pedigree of sickle cell anaemia in a family.


RBC of both parents of the I generation

A
will be normal in shape
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B
will be sickle shaped
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C
will be both normal and sickle shaped
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D
cannot be determined
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Solution

The correct option is C will be both normal and sickle shaped
From the pedigree analysis, it has been found that the parents of I generation have offspring which are affected by sickle cell anaemia. But both the parents show normal phenotype as seen in the pedigree. This is only possible when both the parents are carriers which means both the parents have normal and sickle shaped RBCs.

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