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Question

Glomerular filtrate at the base of Henle's loop is

A
Isotonic
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B
Hypotonic
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C
Hypertonic
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D
Insoluble
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Solution

The correct option is C Hypertonic
Reabsorption in Henle's loop is minimum. However, this region plays a significant role in the maintenance of high osmolarity of medullary interstitial fluid. The descending limb of loop of Henle is permeable to water but almost impermeable to electrolytes. This concentrates the filtrate as it moves down. Thus filtrate at the base of loop is hypertonic. The ascending limb is impermeable to water but allows transport of electrolytes actively or passively. Therefore, as the concentrated filtrate pass upward, it gets diluted due to the passage of electrolytes to the medullary fluid.

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