4
Question
Glucose-6-phosphate dehydrogenase deficiency is associated with haemolysis of
Glucose-6-phosphate dehydrogenase deficiency is associated with haemolysis of
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Solution
The correct option is B RBCs
Glucose 6-phosphate dehydrogenase (G- 6- PDH) is the cytosolic enzyme that catalyzes the following reaction:
D- glucose-6-phosphate + NADP+ --> 6-phospho-d-glucono-1,5-lactone + NADPH + H+.
This enzyme is in the pentose phosphate pathway, that supplies reducing energy to the cells (like RBCs) by maintaining the level of the co-enzyme NADPH. The deficiency of this enzyme creates a condition called favism. This is an X-linked recessive genetic condition that results in the spontaneous destruction of RBCs i.e., hemolysis and resultant jaundice in response to a number of triggers like certain foods, illness, etc.
Thus, the correct answer is option (B), 'RBCs'.
Glucose 6-phosphate dehydrogenase (G- 6- PDH) is the cytosolic enzyme that catalyzes the following reaction:
D- glucose-6-phosphate + NADP+ --> 6-phospho-d-glucono-1,5-lactone + NADPH + H+.
This enzyme is in the pentose phosphate pathway, that supplies reducing energy to the cells (like RBCs) by maintaining the level of the co-enzyme NADPH. The deficiency of this enzyme creates a condition called favism. This is an X-linked recessive genetic condition that results in the spontaneous destruction of RBCs i.e., hemolysis and resultant jaundice in response to a number of triggers like certain foods, illness, etc.
Thus, the correct answer is option (B), 'RBCs'.
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