Question

Good pasture syndrome is an autoimmune disorder in which

• A. autoantibodies against certain domains of type IV collagen are formed
• B. B-cells remain dormant
• C. glial cells multiply
• D. spermatogenesis is completely shut down

Answer 1

The correct option is A autoantibodies against certain domains of type IV collagen are formed

Good pasture syndrome is a rather rare disorder in which injury to the kidney and lung are caused by proliferation of autoantibodies against certain domains of type IV collagen (type of collagen found primarily in the skin within the basement membrane zone). These antibodies attack the basement membranes of these tissues (pulmonary alveoli and renal glomeruli. If immunosuppressants are not provided on time, transplantation of organs might have to be carried out.