Haemoglobin of normal and sickle cell patient are subjected to electrophoresis. They will show _____________.

Same mobility

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Different mobility

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No mobility

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Haemoglobin of patient does not move.

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Solution

The correct option is B Different mobility

In Normal Haemoglobin electrophoresis red cell lysates are subjected to electric fields under alkaline (alkaline gel) and acidic (acid gel) pH. ... A change in the amino acid composition of the globin chains results in alteration of the charge of the hemoglobin molecule, resulting in a change of the speed of migration, but in the haemoglobin of sickle cell patient does not show this type of electrophoresis, because of the reduction of RBC size and activity.
So, the correct option is ‘Different mobility’.

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