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Question

Haemophilia is more common in males because it is a

A
recessive trait which is able to express in homozygous condition
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B
dominant trait carried by Y chromosome
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C
recessive trait which is able to express in hemizygous condition
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D
dominant trait which is able to express in heterozygous condition
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Solution

The correct option is C recessive trait which is able to express in hemizygous condition
Haemophilia is an X linked recessive trait which is caused due to the presence of a mutated gene ‘h’ on the X chromosome of humans.

A human female would be haemophilic if both the X chromosome had h gene ( XhXh) condition. But this condition is very rare in females as it is lethal. Usually the females with such a genotype die early in the embryonic life.

But in males, the case is different. They contain one X chromosome and one Y chromosome. The presence of a mutant allele over the X chromosome is enough to show the phenotypic expression. This is because there is no counter allele on the corresponding Y chromosome. This is the hemizygous condition.
In males, a homozygous condition is not possible because of the presence of two different chromosomes. This condition is not lethal in males. So, haemophilia is mostly seen in males.
It is not a dominant trait and is not present on the Y chromosome.
In females, this disorder is not expressed phenotypically in the heterozygous condition. Though the female carries a single mutant allele, she is not diseased. She leads a normal life.

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