Hardy-Weinberg principle cannot operate if :

Population is large

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Free interbreeding among all members.

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Frequent mutations occur in population

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Population does not interact with other population

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Solution

The correct option is C Frequent mutations occur in population
Hardy-Weinberg equilibrium cannot operate if there are changes in allelic frequencies in the population. Various factors capable of changing allelic frequency are Gene migration or gene flow, Genetic drift, Mutation, Genetic recombination, Natural selection.
So, the correct answer is 'Frequent mutations occur in population'

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Assertion : Hardy - Weinberg principle explains the variations occurring in population and species over a number of generations.

A population will not exist in Hardy-Weinberg equilibrium if:

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