Question

Having lost his sight to sustained eyestrain, John Milton nevertheless composed Paradise Lost, considered by many to be the greatest English epic.

• A. Having lost his sight to sustained eyestrain
• B. With his sight lost to sustained eyestrain
  
• C. Blinded by sustained eyestrain
• D. Having been blinded by excessive eyestrain

Answer 1

The correct option is C

Blinded by sustained eyestrain

None of the Options is overtly wrong in terms of grammar, so focus on expression. Having lost his sight, with his sight lost, and having been blinded are far wordier than blinded. Since blinded accurately captures the same idea, you can eliminate (A), (B) and (D).
Option (C) is the answer.