Dear Parth, Ethanol activates double-stranded RNA (dsRNA)-activated protein kinase (PKR) and PKR activation is involved ethanol-induced neuroinflammation and neurotoxicity in the developing cerebellum. Also, normally Ethanol alters the development of cerebellar circuitry following the loss of neurons of the cerebellum, which could result in modifications of the structure and function of other brain regions that receive cerebellar inputs.