Oparin and Haldane proposed a Oparin Haldane hypothesis. It proposed the chemical evolution of life. According to this hypothesis, the first form of life came from pre-existing non-organic molecules. S.L. Miller supported their proposa. He created Earth's reducing atmosphere during early days of development. He created electric discharge in a closed flask containing methane, hydrogen, ammonia and water vapour at 8000C. This resulted is the formation of amino acids. Hence, this experiment supported that the chemical evolution of organic molecules occurred from the inorganic substances.