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Question

How does ADH contribute to the formation of concentrated urine?


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Solution

ADH hormone:

  1. ADH/Vasopressin/arginine vasopressin (AVP) or argipressin is secreted from the posterior pituitary gland to regulate increased plasma osmolarity.

Role of ADH hormone in urine formation:

  1. Due to the direct control, it has over blood volume, urine volume regulation is a component of homeostasis.
  2. Two key processes, the renin-angiotensin system, and the less complex anti-diuretic hormone (ADH) feedback loop control blood volume and urine production.
  3. Osmoreceptors in the hypothalamus detect the elevated plasma osmolarity, which prompts the pituitary to release ADH. The kidneys' nephrons are then affected by ADH, which results in a drop in plasma osmolarity and a rise in urine osmolarity.
  4. Water retention is increased by ADH because it makes the distal convoluted tubule and collecting duct more permeable to water.
  5. Following ADH's action on the nephron to lower plasma osmolarity, osmoreceptors become inactive, and ADH secretion ceases.


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