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Question

How does ADH prevent diuresis?


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Solution

Role of ADH in diuresis:

  1. Antidiuretic hormone, also known as arginine vasopressin (AVP), is a nine amino acid peptide secreted from the posterior pituitary.
  2. The single most important effect of the antidiuretic hormone is to conserve body water by reducing the loss of water in urine.
  3. The antidiuretic hormone increases the permeability of the collecting ducts of the kidney and promotes the reabsorption of water back into circulation.
  4. It stimulates water reabsorption by stimulating the upregulation of "water channels" or aquaporins into the membranes of kidney tubules.
  5. Diabetes insipidus is the most frequent disease in humans and animals.
  6. When the kidneys stop responding to ADH, nephrogenic diabetes insipidus develops.
  7. If adequate water is available for consumption, the disease is rarely life-threatening, but withholding water can be very dangerous.

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