Question

How does antimycin affect the electron transport chain?

Answer 1

Electron transport chain:

1. An electron transport chain is a collection of protein complexes and other molecules that associate protons across a membrane with the transfer of electrons from electron donors to electron acceptors via redox processes.
2. Streptomyces bacteria create the secondary metabolite antimycin A, or more precisely antimycin A1b, which belongs to the class of substances known as antimycins.
3. Antimycin is a crystalline antibiotic with the molecular formula C₂₈H₄₀N₂O₉ that is primarily employed as a fungicide, insecticide, and miticide.
4. Strong electron transport chain (ETC) inhibitors include antimycin.
5. By preventing the transfer of electrons from cytochrome b to cytochrome c, it prevents the flow of electrons through complex III of the ETC.
6. Antimycin needs Mitochondrial electron transport chain complex III to inhibit autophagy.