Dengue fever has emerged as the most important mosquito-borne viral diseases. Studies suggest that interstitial dendritic cells constitute the first line of the innate host defence against invading dengue virus. There is also early activation of natural killer cells and type-I interferon-dependent immunity which limits viral replication at the early stages of dengue infection. ​Research has shown that some level of protection from the disease is conferred when a person is infected with the virus. However, protection is strain-specific. If an individual, in his/her lifetime is infected with two different strains of dengue virus, the resulting disease-immune system interaction could be deadly.